Thermo Fisher Scientific Angiotensin Converting Enzyme 2 (ACE2) Polyclonal Antibody
ACE2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간 및 마우스 시료에 반응하며 Protein A로 정제된 고순도 항체입니다. ACE2의 생리적 기능 및 SARS-CoV 수용체 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids near the center of human ACE2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 has been identified as a functional receptor for the SARS coronavirus. Its normal function is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, whereas ACE converts AngI to AngII. Lack of ACE2 expression in knockout mice results in severely reduced cardiac contractility, highlighting its importance in heart function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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