Thermo Fisher Scientific PCMT1 Monoclonal Antibody (4G9)
PCMT1 단백질을 인식하는 Thermo Fisher의 mouse monoclonal 항체로, Western blot과 ELISA에 사용 가능. Human 및 Rat 시료에 반응하며, 비결합형 액상 형태로 제공. 단백질 손상 복구 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G9 |
| Immunogen | PCMT1 (AAH07501.1, 1–228 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKCNPYMDSP QSIGFQATIS APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GCTGKVIGID HIKELVDDSV NNVRKDDPTL LSSGRVQLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLQD GSIKMKPLMG VIYVPLTDKE KQWSRDEL
Target Information
Protein carboxyl methyltransferases (PCMTs) are enzymes found in both prokaryotic and eukaryotic cells, classified into three types based on methyl-acceptor substrate specificity.
The type II enzyme (PCMT1, EC 2.1.1.77) transfers methyl groups from S-adenosyl-L-methionine to free carboxyl groups of D-aspartyl and L-isoaspartyl residues.
These residues result from spontaneous deamidation, isomerization, and racemization of L-aspartyl and L-asparaginyl residues, representing covalent damage sites in aging proteins.
PCMT1 functions as a protein repair enzyme, converting abnormal residues back to their normal L-aspartyl form.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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