Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI12D1), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882) for optimal results.

Target Information

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on intracellular lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and peripheral blood granulocytes.
It plays a role in phagocytic activity of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell or cell-pathogen interactions.
CD68 expression is observed in interdigitating reticulum cells in tonsil, histiocytic lymphoma, histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated CD68 expression has been demonstrated in CD34+ cells in various human malignancies, including several AML studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.