Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI12D1), TrueMAB
인간 CD68 단백질(아미노산 22–319)을 인식하는 Mouse IgG1 단클론 항체. Western blot에 최적화된 TrueMAB 포맷으로 제공. 동결건조 형태, PBS 버퍼(8% trehalose) 포함, 보존제 무첨가. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12D1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–319 of human CD68 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882) for optimal results.
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on intracellular lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and peripheral blood granulocytes.
It plays a role in phagocytic activity of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell or cell-pathogen interactions.
CD68 expression is observed in interdigitating reticulum cells in tonsil, histiocytic lymphoma, histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated CD68 expression has been demonstrated in CD34+ cells in various human malignancies, including several AML studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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