Thermo Fisher Scientific RRP4 Polyclonal Antibody
RRP4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 40% glycerol이 포함된 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RRP4. Recombinant protein control fragment (Product #RP-92953). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646820 |
Product Specific Information
Immunogen sequence:
SVILGNNGFI WIYPTPEHKE EEAGGFIANL EPVSLADREV ISRLRNCIIS LVTQRMMLYD TSILYCYEAS LPHQIKDILK PEIMEEIVME TR
Sequence identity:
- Mouse: 87%
- Rat: 91%
Target Information
Non-catalytic component of the RNA exosome complex which has 3’→5’ exoribonuclease activity and participates in various RNA processing and degradation events.
In the nucleus, it is involved in maturation of stable RNA species (rRNA, snRNA, snoRNA) and degradation of defective or non-coding transcripts (e.g., antisense RNA, PROMPTs).
In the cytoplasm, it contributes to general mRNA turnover, degradation of AU-rich element (ARE)-containing mRNAs, and RNA surveillance pathways.
It may also play a role in Ig class switch recombination (CSR) and/or somatic hypermutation (SHM) by targeting AICDA activity.
The Exo-9 core complex serves as a scaffold for catalytic subunits and accessory proteins, with EXOSC2 stabilizing the RNase PH-domain subunit ring via EXOSC4 and EXOSC7 interactions.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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