Thermo Fisher Scientific BIN1 Polyclonal Antibody
BIN1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC에 적합. Human과 Rat 시료에 반응. 항원 친화 크로마토그래피로 정제되어 고순도 확보. PBS/glycerol buffer에 보존되며 연구용으로 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human BIN1 (aa 1–593) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Wet ice |
| RRID | AB_2720499 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by antigen-specific affinity chromatography. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
The BIN1 gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with tumor suppressor characteristics. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus, activating a caspase-independent apoptotic process. Mouse studies suggest an important role in cardiac muscle development. Alternative splicing results in multiple transcript variants encoding different isoforms, and aberrant splice variants have been described in tumor cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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