Thermo Fisher Scientific Phospho-INSR (Tyr972) Polyclonal Antibody
인슐린 수용체(INSR) Tyr972 인산화 상태를 검출하는 Thermo Fisher의 폴리클로날 항체. Western blot 및 면역형광에 최적화. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로 연구용에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 11 publications |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| Functional Assay | - | View 1 publication |
| Miscellaneous PubMed | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of the human insulin receptor containing tyrosine 972 (Ebina et al.), corresponding to tyrosine 960 (Ullrich et al.). Sequence conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533760 |
Target Information
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR cause various insulin resistance syndromes, and IGF-1R defects may also lead to growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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