Thermo Fisher Scientific C1orf51 Polyclonal Antibody
Human C1orf51 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 합성 펩타이드를 면역원으로 제작됨. Affinity Chromatography로 정제된 액상 제품으로, PBS와 2% sucrose buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human C1orf51 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606712 |
Product Specific Information
Peptide sequence:
GRFERGLSSF QQSVAMDRIQ RIVGVLQKPQ MGERYLGTLL QVEGMLKTWF
Sequence homology:
Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 85%
Target Information
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors CRY1, CRY2, and BHLHE41. In a histone deacetylase-dependent manner, it represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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