Thermo Fisher Scientific DCP1A Polyclonal Antibody
Thermo Fisher Scientific의 DCP1A 폴리클로날 항체는 인간 DCP1A 단백질을 인식하며 Western blot에 최적화되어 있습니다. Rabbit IgG 기반으로 제작되었으며 Protein A로 정제된 액상 형태입니다. PBS와 sucrose buffer로 안정화되어 연구용으로 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:750
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human DCP1A (aa 199–248) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2577099 |
Product Specific Information
- Peptide sequence:
EEMPSGSQDK SAPSGHKHLT VEELFGTSLP KEQPAVVGLD SEEMERLPGD - Sequence homology:
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Target Information
Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. Smads relay signals from the cell membrane to the nucleus and influence gene transcription. Smad4 plays an essential role in TGF-beta-induced transcriptional activation, forming complexes with receptor-associated Smads, SMIF, and BMP4. Increased Smad4 concentration enhances nuclear translocation of this complex. SMIF and Smad4 interact through EVH1/WH1 and proline-rich domains, respectively. Deletion of the Smad4-interacting domain in SMIF prevents TGF-beta-induced nuclear translocation. The human SMIF gene is ubiquitously expressed and encodes a 70 kDa protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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