Thermo Fisher Scientific CDKN2A Monoclonal Antibody (OTI13E10), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The CDKN2A gene produces several transcript variants differing in their first exons.
At least three alternatively spliced variants encode distinct proteins, two of which act as inhibitors of CDK4 kinase.
Another variant encodes an alternate open reading frame (ARF) product that stabilizes the tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, the CDK inhibitor isoforms and ARF product share a common role in cell cycle G1 control.
This gene is frequently mutated or deleted in various tumors and is recognized as an important tumor suppressor gene.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.