Thermo Fisher Scientific RNF11 Polyclonal Antibody
Human RNF11 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 ICC/IF 실험에 적합하며, preservative-free 상태로 제공됨. 장기 보관 시 -20°C에서 보관 권장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific RNF11 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of Human RNF11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788477 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human RNF11.
Target Information
RNF11 is an essential component of a ubiquitin-editing protein complex comprising TNFAIP3, ITCH, and TAX1BP1, which regulates inflammatory signaling pathways.
It promotes TNFAIP3 association with RIPK1 after TNF stimulation, enabling TNFAIP3 to deubiquitinate Lys-63 polyubiquitin chains and form Lys-48 polyubiquitin chains, leading to RIPK1 proteasomal degradation and termination of TNF- or LPS-mediated NF-κB activation.
RNF11 also recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, resulting in its degradation by the 26S proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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