Thermo Fisher Scientific PCGF6 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins.
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is composed of a conserved cysteine-rich domain capable of binding two zinc atoms.
Proteins containing the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation.

PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger.
PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.