Thermo Fisher Scientific LPIN1 Polyclonal Antibody
LPIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인간 시료에 반응하며, 4°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 to 275 of human Phosphatidate phosphatase LPIN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2, and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. It selectively activates a subset of PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of the nuclear receptor PPARA.
LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy—a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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