Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
ARHGEF7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. ICC/IF 및 IP 실험에 적합하며, 고순도 Protein G 정제 및 고농도(3.75 mg/mL) 액상 형태로 제공. 인간 단백질에 반응하며, 안정적인 PBS/glycerol buffer로 장기 보관 가능.
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200–1:500
Immunoprecipitation (IP)
- Tested Dilution: 1:200–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Rho guanine nucleotide exchange factor 7 protein (1–250aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.75 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902112 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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