Thermo Fisher Scientific Estrogen Receptor alpha Recombinant Rabbit Monoclonal Antibody (4L8K5)
Estrogen Receptor alpha를 검출하기 위한 Rabbit Monoclonal 항체로, Human, Mouse, Rat에 반응합니다. WB 및 ELISA에 적합하며, HEK293 세포에서 발현된 재조합 항체입니다. 고순도의 Affinity Chromatography 정제 및 안정한 PBS/glycerol buffer로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4L8K5 |
| Immunogen | Synthetic peptide corresponding to amino acids 50–150 of human Estrogen Receptor alpha (ESRα, UniProt ID: P03372) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.7 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911801 |
Product Specific Information
- Positive test control: MCF7
- Subcellular localization: Cell membrane, Cytoplasm, Golgi apparatus, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein
Immunogen sequence:
AVYNYPEGAA YEFNAAAAAN AQVYGQTGLP YGPGSEAAAF GSNGLGGFPP LNSVSPSPLM LLHPPPQLSP FLQPHGQQVP YYLENEPSGY TVREAGPPAF Y
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (EREs) in DNA. Through these interactions, ER can regulate gene transcription by recruiting coactivator or corepressor proteins.
Two main forms exist: ERα (ESR1) and ERβ (ESR2). Alternative RNA splicing generates multiple ERα isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed and play essential roles in sexual development, reproduction, bone physiology, and are implicated in diseases such as breast and endometrial cancers and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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