Thermo Fisher Scientific HPV16 E1/E4 (Human Papilloma Virus 16) Monoclonal Antibody (HPV16 E1/E4)
HPV16 E1/E4 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. IHC(P) 및 IHC(PFA) 적용 가능. HPV16 관련 암 연구용으로 적합하며, 단백질 A/G 정제 및 PBS 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HPV16 E1/E4 |
| Immunogen | Recombinant human HPV16 E1/E4 fragment (aa 36–41) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a high-risk sexually transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancers.
The HPV16 E1/E4 protein is abundantly expressed in cells supporting viral DNA amplification but is lost during malignant progression.
HPV16 E1/E4 induces G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes.
It also interacts with cyclin A and Cdk2 during the G2 phase, enhancing its ability to prevent mitotic entry.
Additionally, HPV16 E1/E4 associates with keratin intermediate filaments and causes the network to collapse.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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