Thermo Fisher Scientific S1P1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human S1P1 receptor. Validated for IHC (Paraffin) at 5 µg/mL. Unconjugated, Protein A purified, supplied in PBS with BSA and sodium azide. Suitable for research use in cell signaling and migration studies.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 1–60 of human S1P1/EDG-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540971 |
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P), coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling activates RAC1, SRC, PTK2/FAK1, and MAP kinases, playing a key role in cell migration through actin cytoskeleton reorganization and lamellipodia formation. It is essential for normal chemotaxis toward S1P, embryonic heart development, and cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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