Thermo Fisher Scientific USP51 Polyclonal Antibody
Thermo Fisher Scientific의 USP51 폴리클로날 항체는 인간 USP51 단백질을 인식하며 Western blot과 면역세포염색에 적합합니다. Rabbit IgG 기반으로 고순도 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로 DNA 손상 반응 및 단백질 탈유비퀴틴화 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 278–307 amino acids from the central region of human USP51 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552584 |
Target Information
USP51 (Ubiquitin Specific Peptidase 51) is a protein-coding gene involved in the ubiquitin-proteasome dependent proteolysis pathway.
Gene Ontology (GO) annotations include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity.
USP51 specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16 (H2AK15Ub) of histone H2A, regulating the DNA damage response at double-strand breaks (DSBs).
It is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1.
Also exhibits activity for Lys-27 or Lys-63-linked di-ubiquitin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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