Thermo Fisher Scientific CD7 Monoclonal Antibody (CD7-6B7), FITC

Applications

• Flow Cytometry (Flow): Assay-dependent
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Product Specifications

Additional Formats

• APC ([MHCD0705])
• PE ([MHCD0704])
• TRI-COLOR ([MHCD0706])
• Request custom conjugation available

Product Specific Information

FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them ideal for flow cytometry applications.

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.

• The N-terminal region (amino acids 1–107) shows high homology to Ig kappa-L chains.
• The carboxy-terminal region is proline-rich, forming a stalk from which the Ig domain projects.
• CD7 is expressed on most immature and mature T-lymphocytes, T cell leukemia cells, NK cells, and a small subset of B cells (both normal and malignant).
• Cross-linking of surface CD7 modulates T and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation.
• CD7 directly associates with phosphoinositol 3'-kinase, inducing D-3 phosphoinositide production and tyrosine phosphorylation.
• CD7 expression is an important diagnostic marker in leukemia.

Classification

Analyte Specific Reagent

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