Thermo Fisher Scientific LRRC33 Polyclonal Antibody
LRRC33 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA 등에 사용 가능. Protein A로 정제된 액상 항체로 인간, 마우스, 랫트 반응성. TGF-beta 활성 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human LRRC33, amino acids 501–600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2, TGFB3) that controls TGF-beta activation by maintaining it in a latent state in the extracellular space. It associates via disulfide bonds with the Latency-associated peptide (LAP), regulating integrin-dependent activation of TGF-beta. LRRC33 competes with LTBP1 for LAP binding and controls activation of TGF-beta-1 (TGFB1) on activated regulatory T-cells (Tregs). It is essential for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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