Thermo Fisher Scientific PTGS2 Monoclonal Antibody (OTI10H5), TrueMAB
인간 PTGS2(COX2)에 특이적인 단클론 항체로 Western blot 및 IHC(파라핀 절편)에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 염증 및 암 연구용으로 COX2 단백질 검출에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–260 of human PTGS2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to prostaglandin H2 is a two-step reaction:
- Cyclooxygenase (COX) reaction converts arachidonate to prostaglandin G2 (PGG2).
- Peroxidase reaction reduces PGG2 to prostaglandin H2 (PGH2).
COX2 is constitutively expressed in certain tissues (endothelium, kidney, brain) under physiological conditions and up-regulated in pathological states such as cancer and inflammation.
Up-regulation is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 promotes production of prostaglandin E2 (PGE2), which modulates motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active Vitamin D) and suppressed by glucocorticoids through transcriptional interference.
It is a known target of NSAIDs such as aspirin, which reduce pain and swelling from COX2-driven inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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