Thermo Fisher Scientific SPAG5 Monoclonal Antibody (5F9)
SPAG5 단백질을 인식하는 Thermo Fisher Scientific의 Mouse monoclonal antibody (Clone 5F9). Western blot과 ELISA에 적합하며, 인간 단백질에 반응합니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F9 |
| Immunogen | SPAG5 (AAH00322, 1082–1191 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AETETKVLQE ALAGQLDSNC QPMATNWIQE KVWLSQEVDK LRVMFLEMKN EKEKLMIKFQ SHRNILEENL RRSDKELEKL DDIVQHIYKT LLSIPEVVRG CKELQGLLEF
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST, or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, and is essential for proper spindle formation. SPAG5 is involved in the dynamic and functional regulation of mitotic spindles, sister chromatid cohesion, and chromatid separation.
Through its association with chromatids, SPAG5 plays a key role in maintaining chromosome integrity. It forms a homodimer with a long stalk and globular head domain, exhibiting aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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