Thermo Fisher Scientific SPAG5 Monoclonal Antibody (5F9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
AETETKVLQE ALAGQLDSNC QPMATNWIQE KVWLSQEVDK LRVMFLEMKN EKEKLMIKFQ SHRNILEENL RRSDKELEKL DDIVQHIYKT LLSIPEVVRG CKELQGLLEF

Target Information

SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST, or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, and is essential for proper spindle formation. SPAG5 is involved in the dynamic and functional regulation of mitotic spindles, sister chromatid cohesion, and chromatid separation.
Through its association with chromatids, SPAG5 plays a key role in maintaining chromosome integrity. It forms a homodimer with a long stalk and globular head domain, exhibiting aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.