Thermo Fisher Scientific TRDC Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000 dilution

Product Specifications

Target Information

The constant region of the T cell receptor (TR) delta chain participates in antigen recognition. Gamma-delta T cell receptors recognize a variety of self and foreign non-peptide antigens, often expressed at epithelial boundaries between the host and external environment. These include endogenous lipids presented by CD1D and phosphoantigens presented by BTN3A1. Upon antigen recognition, they induce rapid, innate-like immune responses involved in pathogen clearance and tissue repair.

Binding of the gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by LCK and FYN kinases, leading to activation of ZAP70 and subsequent phosphorylation of scaffolding proteins LCP2 and LAT. This results in the formation of a supramolecular signalosome that recruits PLCG1, causing calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells.

Gamma-delta TRs are produced through somatic rearrangement of variable (V), diversity (D), and joining (J) genes. Their diversity is enhanced by tandem D gene rearrangements and random nucleotide additions during V-(D)-J recombination.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.