Thermo Fisher Scientific CENPB Polyclonal Antibody
CENPB 단백질을 검출하는 Rabbit Polyclonal Antibody로 Western Blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 항체이며, -20°C에서 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CENPB (Accession P07199), corresponding to amino acid residues N48–I98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899644 |
Product Specific Information
Antibody detects endogenous levels of total CENPB.
Target Information
CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein derived from transposases of the pogo DNA transposon family.
It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus.
This protein recognizes and binds a 17-bp sequence (CENP-B box) in centromeric alpha satellite DNA and plays an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes.
CENPB is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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