Thermo Fisher Scientific Pax2 Polyclonal Antibody, FITC
Thermo Fisher Scientific Pax2 Polyclonal Antibody, FITC는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 기반 폴리클로날 항체로 FITC 형광 표지형입니다. Western blot, ELISA, Immunoprecipitation에 적합하며, 498/517 nm의 형광 특성을 가집니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PAX2-FITC
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid regions 1–50, 255–305, and 310–360 on human PAX2 protein |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pax gene family encodes transcription factors active in specific tissues during early embryonic development. Pax proteins contain a DNA-binding domain encoded by the paired box, enabling them to regulate genetic programs. Mutations in Pax genes are associated with developmental disorders such as:
- Pax-3: Waardenburg syndrome
- Pax-6: Aniridia
- Pax-2: Wilms tumor
During embryogenesis, Pax-2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures. Pax-2 expression decreases as tubular epithelium matures but persists in Wilms tumor, correlating with poorly differentiated epithelial cell proliferation. Expression of the Wilms tumor suppressor WT1 coincides with Pax-2 down-regulation, suggesting WT1 directly represses Pax-2 transcription.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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