Thermo Fisher Scientific COMT Polyclonal Antibody, MaxPab
COMT 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 최적화되어 있으며, 인간 및 생쥐 시료에 반응. Affinity chromatography로 정제된 액상 항체로, PBS(pH 7.4)에 보존제 없이 보관. 연구용 전용 제품.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | COMT (NP_009294.1, 1 a.a. ~ 221 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine. This O-methylation serves as a major degradative pathway for catecholamine neurotransmitters.
COMT also plays an important role in the metabolism of catechol drugs used for hypertension, asthma, and Parkinson’s disease.
COMT exists in two forms in tissues: soluble (S-COMT) and membrane-bound (MB-COMT), differing at their N-termini. Several transcript variants are produced through alternative translation initiation and promoter usage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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