Thermo Fisher Scientific PIEZO1 Monoclonal Antibody (2-10)
PIEZO1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체(2-10). Western blot, IHC, ICC 등 다양한 응용에 적합. Human 및 Mouse 반응성 확인. Protein A 정제, 2 mg/mL 농도, PBS 기반 완충액에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:600 | – |
| Immunocytochemistry (ICC/IF) | 1:100 | View 4 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2-10 |
| Immunogen | Recombinant protein within Human Protein FAM38A (aa 1275–1540) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802511 |
Target Information
Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel that generates currents characterized by a linear current–voltage relationship, sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. It plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling.
In the kidney, Piezo1 may contribute to detection of intraluminal pressure changes and urine flow sensing. It acts as a shear-stress sensor promoting endothelial cell alignment and vascular formation. Mutations in the PIEZO1 gene are associated with dehydrated hereditary stomatocytosis and lymphedema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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