Thermo Fisher Scientific OAZ3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human OAZ3. Recombinant protein control fragment (Product #RP-105822). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OAZ3,uniProtId:Q9UMX2-1,ncbiNodeId:9606,antigenRange:179-235,antigenLength:235,antigenImageFileName:PA5-65056_OAZ3_Q9UMX2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65056_OAZ3_Q9UMX2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2665157

Product Specific Information

Immunogen sequence: VNFQNDRNDRG ALLRAFSYMG FEVVRPDHPA LPPLDNVIFM VYPLERDVGH LPSEPP

Highest antigen sequence identity to the following orthologs - mouse 82%, rat 77%.

Target Information

The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine. AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that belongs to the ODC antizyme family. AZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase. However, mutations in the AZ3 gene are not a common cause of male infertility and the normal AZ3 protein does not accelerate ornithine decarboxylase degeneration. AZ3 expression has a sharp onset in early spermatids, peaks in later stages and is gone in spermatozoa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.