Thermo Fisher Scientific Phospho-SHP2 (Tyr542) Monoclonal Antibody (16A12)
SHP2 단백질의 Tyr542 인산화 형태를 특이적으로 인식하는 단클론 항체. Western blot에 최적화되어 있으며, 세포 신호전달 연구에 유용. Rabbit IgG 형식으로 제공되며, 액상 상태로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A12 |
| Immunogen | Synthetic peptide derived from human SHP2 (Y542), between 500–600 amino acids |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, which regulates key cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 (SH2) domains that mediate phospho-tyrosine binding and substrate interaction.
It is broadly expressed across tissues and plays a critical role in multiple signaling pathways involved in mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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