Thermo Fisher Scientific CYFIP2 Polyclonal Antibody
CYFIP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 분석에 적합. 인간 및 마우스 시료 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용에 적합.
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Thermo Fisher Scientific CYFIP2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human cytoplasmic FMR1 interacting protein 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635841 |
Product Specific Information
The antibody detects endogenous levels of total CYFIP2 / PIR121 protein.
Target Information
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2.
It belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis.
CYFIP2 interacts with FMR1, FXR1, and FXR2 and is a component of the WAVE1 complex (Abi-2, CYFIP2, C3orf10/HSPC300, NAP125, WASF1/WAVE1).
Upon binding to activated Rac1, CYFIP2 causes the complex to dissociate, releasing activated WASF1.
The CYFIP2 promoter contains a p53-responsive element that allows p53 binding and transcriptional activation.
Induced expression of CYFIP2 can trigger caspase activation and cellular apoptosis, similar to p53 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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