Thermo Fisher Scientific GAB2 Polyclonal Antibody
GAB2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에서 반응합니다. Western blot과 ELISA에 사용 가능하며, 고순도 친화 크로마토그래피로 정제된 액상 항체입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific GAB2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 377–676 of human GAB2 (NP_5367391) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805253 |
Product Specific Information
Immunogen sequence:
ENSRSVAATI PRRNTLPAMD NSRLHRASSC ETYEYPQRGG ESAGRSAESM SDGVGSFLPG KMIVGRSDST NSEDNYVPMN PGSSTLLAME RAGDNSQSVY IPMSPGAHHF DSLGYPSTTL PVHRGPSRGS EIQPPPVNRN LKPDRKAKPT PLDLRNNTVI DELPFKSPIT KSWSRANHTF NSSSSQYCRP ISTQSITSTD SGDSEENYVP MQNPVSASPV PSGTNSPAPK KSTGSVDYLA LDFQPSSPSP HRKPSTSSVT SDEKVDYVQV DKEKTQALQN TMQEWTDVRQ SSEPSKGAKL
Positive Samples: HeLa, Mouse kidney
Cellular Location: Cell membrane, Cytoplasm
Target Information
This gene belongs to the GRB2-associated binding protein (GAB) family. GAB proteins contain a pleckstrin homology (PH) domain and interact with SHP2 tyrosine phosphatase and GRB2 adapter protein. They serve as adapters transmitting signals in response to cytokine and growth factor receptors, as well as T- and B-cell antigen receptors. The encoded protein acts as a principal activator of phosphatidylinositol-3 kinase upon activation of the high-affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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