Thermo Fisher Scientific RC3H1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RC3H1. Recombinant protein control fragment (Product #RP-94232). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RC3H1,uniProtId:Q5TC82-1,ncbiNodeId:9606,antigenRange:437-523,antigenLength:1133,antigenImageFileName:PA5-55615_RC3H1_Q5TC82-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55615_RC3H1_Q5TC82-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646417

Product Specific Information

Immunogen sequence: AHSQEELEKF RKMNKRLVPR RPLSASLGQL NEVGLPSAAI LPDEGAVDLP SRKPPALPNG IVSTGNTVTQ LIPRGTDPSY DSSLKPG

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 32%.

Target Information

The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1- mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.