Thermo Fisher Scientific IGF1R alpha Recombinant Rabbit Monoclonal Antibody (11)

Applications

Tested Dilution

• ELISA: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal-origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human IGF1R/CD221.

Target Information

IGF1R (Insulin-like Growth Factor 1 Receptor, CD221) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers. The protein is a tetramer consisting of two alpha and two beta subunits. The alpha subunits bind IGF-1 with higher affinity than IGF-2, leading to conformational change and autophosphorylation at positions 1134, 1135, and 1136. Activated IGF-1R phosphorylates substrate proteins, sequentially activating RAS, RAF, and MAPK isoforms (ERK, p38, JNK), which drive gene transcription for proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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