Thermo Fisher Scientific Granulocyte-Colony Stimulating Factor (G-CSF) Monoclonal Antibody (SPM468)

Thermo Fisher Scientific Granulocyte-Colony Stimulating Factor (G-CSF) Monoclonal Antibody (SPM468)

Applications and Tested Dilution

Product Specifications

Target Information

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
This pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. It has specific effects on the proliferation, differentiation, and activation of hematopoietic cells.

G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. It is encoded by two distinct DNA sequences, resulting in a full-size, high-activity and a shorter, low-activity isoform.
Highly conserved among species, G-CSF exerts its biological functions through interaction with its receptor expressed on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.

Clinical use of G-CSF has been approved for several therapeutic applications including:

• Treatment of neonatal infections
• Therapy of acute myocardial infarction
• Granulocyte transfusion in patients with neutropenia
• Severe infections and sepsis
• Chronic autoimmune neutropenia
• Acute myeloid leukemias, Sweet’s syndrome, and AIDS

G-CSF has also been shown to be a marker protein for various carcinomas such as bladder cancer, and dysfunction of the protein has been linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.