Thermo Fisher Scientific GPR149 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 7–18 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Pig (100%)
Rabbit (93%)
Elephant, Bovine (87%)

Target Information

This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors, which is important for efficient G protein-coupled signal transduction.

Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins. The activated G proteins then bind to and activate numerous downstream effector proteins, generating second messengers that mediate a broad range of cellular and physiological processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.