Thermo Fisher Scientific TLX3 Polyclonal Antibody
Human TLX3 단백질에 특이적인 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관됩니다. TLX3 관련 신경 발달 및 T-ALL 연구에 활용 가능합니다.
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- PA583146
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TLX3. Recombinant protein control fragment (Product # RP-108335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790302 |
Product Specific Information
Immunogen sequence:
APFEDAGSYS VNLSLAPAGV IRVPAHRPLP GAVPPPLPSA LPAMPSVPTV SSLGGLNFPW MESSRRFVKD RFTA
Target Information
The Hox proteins play a role in embryonic development and cellular differentiation by regulating downstream target genes.
TLX3 (also known as HOX11L2) is a DNA-binding nuclear transcription factor expressed in a subset of the primary sensory nervous system.
TLX3, along with TLX1, promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype, opposing LBX1 signals during dorsal spinal cord development.
Chromosomal translocations of the TLX3 gene have been associated with certain forms of T-cell acute lymphoblastic leukemia (T-ALL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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