Thermo Fisher Scientific STIM2 Polyclonal Antibody
Human STIM2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태로 제공. 연구용으로 Ca++ 신호 조절 관련 단백질 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STIM2. Recombinant protein control fragment (Product #RP-102755). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790520 |
Product Specific Information
Immunogen sequence:
WGSPDCVGLT ETKSMIFSPA SKVYNGILEK SCSMNQLSSG IPVPKPRHTS CSSAGNDSKP VQEAPSVARI SSIP
Target Information
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are composed of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which functions as a Ca++ sensor and activates CRAC channels by migrating to the plasma membrane from ER-like sites acting as Ca++ stores.
STIM2, a related molecule, inhibits STIM1-mediated store-operated Ca++ entry and can form complexes with STIM1, suggesting a coordinated role in controlling Ca++ influx. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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