Thermo Fisher Scientific Phospho-TEK (Tyr1113) Polyclonal Antibody
Phospho-TEK (Tyr1113) 항체로 인간 TEK 단백질의 인산화 부위를 특이적으로 인식합니다. Rabbit Polyclonal 형식이며 Dot blot에 사용됩니다. Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA512992
- 판매단위
- pk
카탈로그
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Applications
- Dot blot (DB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1113 of human TEK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2203230 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, and zebrafish based on sequence homology.
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development. Immunoblotting showed that TIE2 expression increases with thyroid-stimulating hormone and agents that elevate intracellular cAMP. Hematopoietic stem cells expressing TIE2 are quiescent and antiapoptotic, forming a side population adhering to osteoblasts within the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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