Thermo Fisher Scientific BZRP Monoclonal Antibody (3D8-B2)
Thermo Fisher Scientific의 BZRP Monoclonal Antibody (3D8-B2)는 인간 BZRP 단백질을 인식하는 Mouse IgG1 항체로, Western blot 및 ELISA에 적합합니다. 단클론 항체로 높은 특이성과 재현성을 제공하며, PBS 용액 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D8-B2 |
| Immunogen | BZRP (AAH01110.1, 1 a.a. – approximately 169 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFATTL NYCVWRDNHG WHGGRRLPE
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an essential component of the steroidogenic machinery, mediating cholesterol delivery to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR consists of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier. It is conserved from bacteria to humans and is widely expressed in peripheral organs, while in the brain, it is mainly localized in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by affecting PBR mRNA stability, reducing PBR expression, cholesterol transport into mitochondria, and subsequent steroid formation. PRAX-1 (peripheral benzodiazepine receptor-associated protein 1) specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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