ELK Biotechnology IL-6Rα rabbit pAb
IL-6Rα rabbit pAb는 인간, 랫, 마우스 시료에서 IL-6 수용체 알파 서브유닛을 검출하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용 가능. 내부 영역 펩타이드로 면역화되어 높은 특이성과 재현성을 제공합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
IL-6Rα rabbit pAb
대체 명칭
IL6R; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC-p: 100–300; Western Blot: 1/500–1/2000; ELISA: 1/10000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human IL6R (AA range: 221–270) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| GeneID (Human) | 3570 |
| Human Swiss-Prot No | P08887 |
| Cellular Localization | Isoform 1: Cell membrane (Single-pass type I membrane protein); Isoform 2: Secreted; Soluble interleukin-6 receptor subunit alpha: Secreted |
| Species Reactivity | Human; Rat; Mouse |
배경 정보
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit shared by many other cytokines.
Dysregulated production of IL6 and its receptor are implicated in diseases such as multiple myeloma, autoimmune disorders, and prostate cancer.
Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
(Provided by RefSeq, May 2011)
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