ELK Biotechnology C4a/b rabbit pAb
C4a/b 단백질을 인식하는 토끼 폴리클로날 항체로, 인간·쥐·마우스 시료에 반응합니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 고순도의 IgG 형태로 제공됩니다. 보관은 -20°C에서 1년 안정적입니다.
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제품명
C4a/b rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | C4A; CO4; CPAMD2; Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4B; CO4; CPAMD3; Complement C4-B; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human C4A/C4B (AA range: 721–770) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kDa |
| Gene ID (Human) | 720 / 721 |
| Human Swiss-Prot No. | P0C0L4 / P0C0L5 |
| Cellular Localization | Secreted; Cell junction, synapse; Cell projection, axon; Cell projection, dendrite |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single-chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
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