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ELK Biotechnology RSAD2 rabbit pAb
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RSAD2 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 RSAD2 N-말단 펩타이드로 면역화. 항바이러스 연구 및 세포 내 위치 분석에 적합. -20°C 보관, 1 mg/ml 농도.
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- ES4264-xxxxx (2개 옵션)
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ELK Biotechnology ES4264-100UL RSAD2 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES4264-50UL RSAD2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology RSAD2 rabbit pAb
RSAD2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RSAD2 rabbit pAb |
| Alternative Names | RSAD2; CIG5; Radical S-adenosyl methionine domain-containing protein 2; Cytomegalovirus-induced gene 5 protein; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the N-terminal region of human RSAD2 (AA range: 21–70) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa |
| Gene ID (Human) | 91543 |
| Human Swiss-Prot No. | Q8WXG1 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side; Golgi apparatus; Lipid droplet; Mitochondrion (inner and outer membranes). Infection with human cytomegalovirus (HCMV) causes relocation to Golgi apparatus and cytoplasmic vacuoles containing HCMV proteins (glycoprotein B, pp28). Interaction with HCMV/HHV-5 protein vMIA/UL37 results in relocalization from ER to mitochondria. |
Background
- Cofactor: Binds one 4Fe-4S cluster coordinated with three cysteines and an exchangeable S-adenosyl-L-methionine.
- Function: Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, essential for budding of many viruses. Acts by binding and inactivating FPPS, an enzyme involved in cholesterol, farnesylated and geranylated proteins, ubiquinones, dolichol, and heme synthesis. Plays a major role in the antiviral state induced by type I and II interferons. Displays antiviral effects against HIV-1, hepatitis C virus, human cytomegalovirus, and alphaviruses, but not vesiculovirus.
- Induction: Induced by interferon type I, type II, and LPS. Little or no induction by interferon gamma in monocytic cell lines. Upregulated by infection with HCMV, hepatitis C virus, yellow fever virus, and Sendai virus via type I interferon pathway.
- Miscellaneous: Up-regulated in atherosclerosis. Latent viruses like HCMV may contribute to atherogenesis by initiating local inflammation, inducing RSAD2 expression, modulating lipid synthesis, and contributing to lipid accumulation.
- Similarity: Belongs to the RSAD2 family.
- Subunit: Interacts with FPPS.
- Subcellular Location: Associates with the cytosolic side of the endoplasmic reticulum; relocates to Golgi apparatus and vacuoles containing viral proteins upon infection.
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