ELK Biotechnology TERT rabbit pAb

ELK Biotechnology TERT rabbit pAb

제품 개요

TERT rabbit polyclonal antibody는 인간 TERT 단백질의 C-말단 펩타이드로부터 생산된 항체로, 텔로머레이스 연구 및 세포 노화 관련 연구에 활용됩니다.

제품 정보

세포 내 위치

• Nucleus, nucleolus
• Nucleus, nucleoplasm
• Chromosome, telomere
• Cytoplasm
• Nucleus, PML body
• Shuttling between nuclear and cytoplasm depending on cell cycle, phosphorylation states, transformation, and DNA damage
• Diffuse localization in the nucleoplasm
• Enriched in nucleoli of certain cell types
• Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707
• Dephosphorylation at this site by SHP2 retains TERT in the nucleus
• Translocated to the nucleus by phosphorylation by AKT

Background

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by adding telomere repeat sequences (TTAGGG). The enzyme consists of a protein component with reverse transcriptase activity and an RNA template component. Telomerase expression is repressed in postnatal somatic cells, leading to telomere shortening and cellular senescence. Deregulation may contribute to oncogenesis. In mouse models, telomerase also participates in chromosomal repair, synthesizing telomere repeats at double-stranded breaks. Multiple alternatively spliced variants of telomerase reverse transcriptase have been identified.

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