ELK Biotechnology HLA-DQB1/2 rabbit pAb

제품명

HLA-DQB1/2 rabbit pAb

주요 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Endosome membrane; Single-pass type I membrane protein.
Lysosome membrane; Single-pass type I membrane protein.
The MHC class II complex transits through multiple intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Background

Major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) belongs to the HLA class II beta chain paralogs.
This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both membrane-anchored.
It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
The beta chain is approximately 26–28 kDa and contains six exons:

• Exon 1: leader peptide
• Exons 2 & 3: extracellular domains
• Exon 4: transmembrane domain
• Exon 5: cytoplasmic tail

Within the DQ molecule, both alpha and beta chains contain polymorphisms specifying peptide-binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow studies.