ELK Biotechnology Syntaxin 1 rabbit pAb
Syntaxin 1 rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능합니다. 신경계 시냅스 소포막 단백질 STX1A를 인식하며, 시냅스 소포 융합 및 이온 채널 조절 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology Syntaxin 1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Syntaxin 1 rabbit pAb |
| Alternative Names | STX1A; STX1; Syntaxin-1A; Neuron-specific antigen HPC-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human STX1A (AA range: 31-80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kDa |
| Gene ID (Human) | 6804 |
| Human Swiss-Prot No. | Q16623 |
| Cellular Localization | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein; Cell junction, synapse, synaptosome; Cell membrane; Colocalizes with KCNB1 at the cell membrane; Isoform 2: Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE (Soluble NSF Attachment protein Receptor) domain (H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent manner and interact with voltage-dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Sep 2009).
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