ELK Biotechnology ApoA-I rabbit pAb
ApoA-I rabbit polyclonal antibody for WB, IHC, IF, and ELISA applications. Recognizes human APOA1 internal region (AA 81–130). Suitable for detecting secreted HDL-associated ApoA-I protein. Stored at -20°C, 1 mg/ml concentration.
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ApoA-I rabbit pAb
Supplier: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ApoA-I rabbit pAb |
| Alternative Names | APOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000; IHC-p: 1/100–1/300; ELISA: 1/20000 (Not yet tested in other applications) |
| Immunogen | Synthesized peptide derived from the internal region of human APOA1 (AA range: 81–130) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 31 kD |
| GeneID (Human) | 335 |
| Human Swiss-Prot No | P02647 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Mouse |
Background
This gene encodes apolipoprotein A-I, the major protein component of high-density lipoprotein (HDL) in plasma. The mature protein promotes cholesterol efflux from tissues to the liver for excretion and acts as a cofactor for lecithin cholesterol acyltransferase (LCAT), responsible for forming most plasma cholesteryl esters. The gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies (e.g., Tangier disease) and systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one encoding a preproprotein. (RefSeq, Dec 2015)
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