ELK Biotechnology IDH1 rabbit pAb
IDH1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. N-말단 유래 합성 펩타이드로 면역화. 세포질 및 퍼옥시좀에 위치한 IDH1 단백질 검출에 적합.
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제품명
IDH1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
IDH1 단백질을 표적하는 토끼 폴리클로날 항체로, 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용 가능합니다. 인간, 마우스, 랫트 시료에서 반응성을 보이며, 세포질 및 퍼옥시좀에 존재하는 IDH1 단백질 검출에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | IDH1 rabbit pAb |
| Alternative Names | IDH1; PICD; Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the N-terminal region of human IDH1 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 46 kD |
| GeneID (Human) | 3417 |
| Human Swiss-Prot No | O75874 |
| Cellular Localization | Cytoplasm, cytosol, peroxisome |
| Species Reactivity | Human; Mouse; Rat |
Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses: one utilizes NAD(+) and the other NADP(+) as electron acceptors. Five isocitrate dehydrogenases have been reported — three NAD(+)-dependent enzymes localized to the mitochondrial matrix, and two NADP(+)-dependent enzymes, one mitochondrial and one cytosolic. Each NADP(+)-dependent isozyme is a homodimer.
The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains a PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2,4-dienoyl-CoAs.
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