ELK Biotechnology Smad1 rabbit pAb
Smad1 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. BMP 신호전달 관련 연구에 활용되며, 고순도 IgG 형태로 -20°C에서 1년간 안정 저장 가능합니다. Human, Mouse, Rat 시료에 반응합니다.
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제품명
Smad1 rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from Smad1 (AA range: 150–230) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 52 kD |
| GeneID (Human) | 4086 |
| Human Swiss-Prot No | Q15797 |
| Cellular Localization | Cytoplasm, Nucleus. Cytoplasmic in the absence of ligand; migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the SMAD family, homologous to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways. Smad1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP stimulation, Smad1 is phosphorylated and activated by BMP receptor kinases, forming a complex with SMAD4 for transcriptional regulation. It is targeted by SMAD-specific E3 ubiquitin ligases such as SMURF1 and SMURF2, undergoing ubiquitination and proteasomal degradation.
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