
ELK Biotechnology p73 rabbit pAb
TP73 단백질을 표적하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인간, 랫, 마우스 반응성. 핵 및 세포질에 위치하며 DNA 손상 시 핵에 축적. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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ELK Biotechnology p73 rabbit pAb
제품 개요
p73 rabbit polyclonal antibody는 인간 TP73 단백질을 인식하며, p53과 유사한 전사 인자로서 세포 스트레스 반응 및 발달 과정에 관여합니다. 본 항체는 다양한 종에서 반응성을 가지며, WB, IHC, IF, ELISA 등 여러 응용에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | p73 rabbit pAb |
| Alternative Names | TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p73 around Lys321 (non-acetylation site), AA range: 281–330 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| GeneID (Human) | 7161 |
| Human Swiss-Prot No | O15350 |
| Cellular Localization | Nucleus, Cytoplasm; accumulates in the nucleus in response to DNA damage |
| Species Reactivity | Human; Rat; Mouse |
Background
Tumor protein p73 (TP73) is a member of the p53 family of transcription factors involved in cellular stress responses and development. It maps to chromosome 1p36, a region often deleted in neuroblastoma and other tumors, suggesting the presence of multiple tumor suppressor genes. TP73 is monoallelically expressed (likely maternal allele) and considered a candidate gene for neuroblastoma. Various transcript variants exist due to alternative splicing and promoter usage, though the biological validity of some remains uncertain.
[Provided by RefSeq, Feb 2011]
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