ELK Biotechnology Amphiphysin II rabbit pAb
Amphiphysin II 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 C-말단 유래 펩타이드로부터 제작되었으며, 1 mg/ml 농도로 제공됩니다. BIN1 관련 연구 및 세포 내 국소화 분석에 활용 가능합니다.
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Amphiphysin II rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Amphiphysin II rabbit pAb |
| Alternative Names | BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Amphiphysin II |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 64 kDa |
| Gene ID (Human) | 274 |
| Human Swiss-Prot No. | O00499 |
| Cellular Localization | [Isoform BIN1]: Nucleus, Cytoplasm, Endosome, Cell membrane (sarcolemma, T-tubule) [Isoform IIA]: Cytoplasm |
| Species Reactivity | Mouse; Rat |
Background
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in muscle and ubiquitously expressed variants localize to the cytoplasm and nucleus, activating a caspase-independent apoptotic process. Studies in mice suggest that this gene plays an important role in cardiac muscle development. Alternate splicing results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]
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