ELK Biotechnology Siglec-5/14 rabbit pAb
Siglec-5/14 단백질을 인식하는 ELK Biotechnology의 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. 1 mg/ml 농도의 IgG 형식이며, 인간, 랫, 마우스 시료에 반응합니다. 세포막 단백질 검출 및 면역학 연구에 활용됩니다.
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Siglec-5/14 Rabbit Polyclonal Antibody
제품 개요
Siglec-5/14 rabbit pAb는 sialic acid-binding immunoglobulin-like lectin (Siglec) 계열 단백질을 인식하는 항체로, CD33 관련 Siglec 하위군에 속합니다. 이 항체는 단핵세포, 대식세포, 호중구 등의 활성화를 억제하는 단백질 연구에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product Name | Siglec-5/14 rabbit pAb |
| Alternative Names | SIGLEC5; CD33L2; OBBP2; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD170; SIGLEC14; Sialic acid-binding Ig-like lectin 14; Siglec-14 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from Sialic acid-binding Ig-like lectin 5/14 (AA range: 91–140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 8778 |
| Human Swiss-Prot No. | O15389 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein belongs to the CD33-related subset of Siglecs and inhibits activation of several cell types, including monocytes, macrophages, and neutrophils. Binding of group B Streptococcus (GBS) to this protein plays a role in GBS immune evasion. [RefSeq, Feb 2012]
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